PAC1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G16941 (symbol PAC1) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with a PAC1-like LisH domain and WD40 repeats characteristic of the LIS1 family of dynein regulators. The product binds dynein complexes and microtubule plus ends. It is associated with microtubule organizing center organization, vesicle transport along microtubules, microtubule sliding, mitotic spindle orientation, nuclear movement, cell communication, signaling, homeostasis, and cell division. The protein localizes to the microtubule associated complex, cytoplasmic microtubule, spindle pole, kinetochore, nuclear envelope, and cytoplasm. Related genes in other species link the family to germination rate and oxidative stress response, though these associations are not yet established in F. graminearum.