FIP1 — Fusarium graminearum PH-1

Summary

FgFIP1 (FGRAMPH1_01G17245) on chromosome 3 of Fusarium graminearum PH-1 encodes a member of the FTR1/Fip1/EfeU family and is annotated with high-affinity ferrous iron transmembrane transporter activity. The gene is associated with reductive iron assimilation, cellular response to iron ion starvation, and regulation of gene expression, with the product localised to the high-affinity iron permease complex, Golgi complex, and plasmalemma. Phenotypic associations include decreased filamentous growth, sporulation efficiency, and fermentative growth, as well as increased stress resistance, metal resistance, and innate thermotolerance, alongside abnormal budding, cell shape, and cell size. Studies of related FTR1/Fip1 family members in other species link the family to reduced virulence and invasive growth.