CAF5 — Fusarium graminearum PH-1

Summary

FgCAF5 (FGRAMPH1_01G17609) on chromosome 3 of Fusarium graminearum PH-1 encodes a major facilitator superfamily (MFS) transporter with transmembrane transporter activity, including fluconazole, xenobiotic, and spermine transmembrane transporter activities. The gene is associated with responses to antibiotics, xenobiotic stimuli, and oxidative stress, as well as spermidine and spermine transmembrane transport and xenobiotic detoxification by export across the plasma membrane. It is linked to the peroxisome membrane, Golgi complex, endoplasmic reticulum, and plasma membrane. Associations include increased filamentous growth, decreased sporulation efficiency, altered cell cycle progression, increased stress resistance, and decreased viability. Related genes in other species are linked to reduced virulence and oxidative stress response.