ubp15 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G17971 (symbol ubp15) on chromosome 3 of Fusarium graminearum PH-1 encodes a deubiquitinase with thiol-dependent deubiquitinase, metal-dependent deubiquitinase and endopeptidase activities, belonging to the peptidase C19 (ubiquitin-specific protease) family. The gene is associated with deubiquitination, ubiquitin-dependent proteolysis, free ubiquitin chain depolymerization, regulation of protein stability, mitotic DNA replication maintenance of fidelity, downregulation of mutagenic PRR, carbon catabolite repression of transcription, ATP export, endosome membrane budding, endocytosis, autophagy, and proteolysis. Its product localizes to the late endosome membrane, proteasome, cell tip, nucleolus, cell division site, Golgi complex, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to ubiquitin processing.