SET2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G18203 (SET2) on chromosome 3 of Fusarium graminearum PH-1 encodes a SET domain-containing protein with histone H3K36 methylase, dimethylase and trimethylase activities, and RNA-binding capacity. The gene is associated with chromatin and nuclear localisation, and with biological processes including DNA-templated transcription elongation and termination, suppression of meiotic recombination, ascospore formation, secondary metabolism, and methylation. Phenotypic associations link SET2 to abnormal mating response, increased sporulation, decreased spore germination, delayed meiotic recombination, arrested meiosis, increased transposable element transposition, altered cell cycle progression (including delayed G2/M and increased G1/S transitions), and absent alkaline pH resistance. Related genes in other species are associated with reduced virulence and acid sensitivity.