SLX1 — Fusarium graminearum PH-1

Summary

FgSLX1 (FGRAMPH1_01G18927) on chromosome 3 of Fusarium graminearum PH-1 encodes an endodeoxyribonuclease with 5' flap endonuclease activity and zinc binding, belonging to the SLX1 endonuclease family with GIY-YIG and RING/FYVE/PHD domains. The gene is associated with homologous recombination repair (HDR) and has been linked to abnormal mitotic recombination, delayed meiotic recombination and sporulation, increased mutation frequency, decreased lifespan, and altered cell cycle progression including S phase arrest and premature metaphase/telophase transitions. It also shows connections to budding patterns, cell size abnormalities, and growth arrest. Related genes in other species link the family to DNA repair and replication fork stability.