PAR1 — Fusarium graminearum PH-1

Summary

FgPAR1 (FGRAMPH1_01G19463) on chromosome 3 of Fusarium graminearum PH-1 encodes a large multi-domain protein containing Tra1_central, Tra1_ring, DDR_Repair_Kinase, PI3/4-kinase catalytic, ARM-type and FAT domains, with protein serine/threonine kinase activity, ATP binding, pre-rRNA binding, protein complex binding, and chromatin adaptor functions. The gene is associated with TORC1 and TORC2 signaling, DNA damage response signal transduction, positive regulation of cytoplasmic translation and ribosomal protein gene transcription, negative regulation of rDNA heterochromatin formation and macroautophagy, and regulation of cell cycle progression including G1/S transition and mitotic entry. It localizes to TOR complexes, nucleolar chromatin, the TIP60 histone acetylase complex, and vacuolar membrane. Phenotypic associations include decreased cell cycle progression rate, altered autophagy and pexophagy, increased mating-type switching, absent X-ray resistance, abnormal sporulation efficiency, and decreased hypoosmotic stress resistance.