FOR — Fusarium graminearum PH-1

Summary

FgFOR (FGRAMPH1_01G19959) on chromosome 3 of Fusarium graminearum PH-1 encodes a serine hydroxymethyltransferase, an enzyme with glycine hydroxymethyltransferase activity that binds pyridoxal phosphate and belongs to the Ser_HO-MeTrfase family. The gene is associated with tetrahydrofolate metabolism and interconversion, as well as asexual and sexual reproduction, vacuolar protein sorting, and endocytosis. Its product localises to mitochondria, cytoplasm, cytosol, and the fungal biofilm matrix. Phenotypic associations link FgFOR to arrested meiosis, decreased S-phase progression, absent respiratory metabolism, abnormal plasma membrane morphology, increased chromosome maintenance, decreased prion inheritance, absent budding, increased critical cell size at the G1 checkpoint, premature cell cycle progression in metaphase and telophase, increased fermentative metabolism, decreased colony size, and abnormal cytokinesis, among many other cell cycle and growth traits. Related genes in other species are linked to serine hydroxymethyltransferase activity (EC 2.1.2.1) and turgor pressure.