VAM3 — Fusarium graminearum PH-1

Summary

FgVAM3 (FGRAMPH1_01G20657) on chromosome 3 of Fusarium graminearum PH-1 encodes a syntaxin-domain SNARE protein, a member of the T-SNARE family. The gene is associated with SNARE binding and SNARE complex formation, and is linked to Golgi-to-vacuole transport, vesicle fusion, intracellular protein transport, and membrane fusion. It localizes to the endomembrane system, including the late endosome, fungal-type vacuole membrane, Golgi complex, and ER. FgVAM3 is associated with abnormal sporulation efficiency, absent vacuolar morphology, delayed protein transport and endocytosis, abnormal nuclear fusion during mating, increased hydrostatic pressure and alkaline pH resistance, abnormal autophagy, septum formation, and cell cycle progression. It is also linked to increased entry into G0 phase and altered pheromone sensitivity.