ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G21057) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABC transporter with domains characteristic of the ABC transporter C-like family, including transmembrane and ATP-binding domains, and exhibits ATP hydrolase, heme-binding, and cadmium ion transmembrane transporter activities. The gene is associated with heme export from the vacuole to the cytoplasm, cellular detoxification of cadmium ions, glutathione and phytochelatin transport into the vacuole, xenobiotic detoxification via plasma membrane export, and homotypic vacuole fusion. It is also linked to filamentous growth in response to starvation and biotic stimuli, secretion, interaction with the host, and sterol and cichorine anabolism. The product localises to the fungal-type vacuole membrane, plasma membrane, Golgi complex, and extracellular vesicles. Studies of related genes in other species connect the family to vacuolar morphology, endocytosis, cell cycle progression, and stress resistance.