CLM1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G22293 (symbol CLM1) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a trichodiene synthase domain and an isoprenoid synthase domain superfamily, possessing carbon-oxygen lyase activity acting on phosphates and metal binding. The gene is directly annotated to culmorin anabolism, mycotoxin anabolism, and detoxification. Studies of related genes in other species link the CLM1 family to increased virulence (hypervirulence) and association with fusarium head blight on Triticum hosts, as well as connections to Fusarium oxysporum f. sp. cubense TR4 and Fusarium oxysporum f. sp. lycopersici.