BML — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G22713 (symbol BML, also known as FgTUB2, TUB2, FgNDA3, NDA3) on chromosome 4 of Fusarium graminearum PH-1 encodes a beta-tubulin protein and is annotated as a structural constituent of the cytoskeleton with GTPase activity, GTP binding, and metal binding. The gene is associated with microtubule cytoskeleton organization, mitotic spindle organization, mitotic chromosome segregation, supramolecular fiber organization, hyphal growth, asexual and sexual reproduction, vacuole fusion, endocytosis, protein folding, and response to antibiotic. It localizes to microtubules and the cytoplasm. Phenotypic associations include abnormal colony size, cell cycle progression defects (delayed or arrested mitosis, premature metaphase-anaphase transition), abnormal meiosis, increased polyploidy and aneuploidy, decreased chromosome segregation, absent apoptosis, delayed autophagy, and abnormal nuclear fusion during mating. Studies of related genes in other species link the family to mitotic cell cycle delay and decreased cold sensitivity.