ARTA — Fusarium graminearum PH-1

Summary

FgARTA (FGRAMPH1_01G23321) on chromosome 4 of Fusarium graminearum PH-1 encodes a 14-3-3 domain-containing protein with protein sequestering activity. This gene is associated with multiple cell cycle checkpoints, including mitotic cytokinesis, mitotic G2 DNA damage, and S-M checkpoints, as well as meiotic cell cycle progression. It has been linked to filamentous growth in response to neutral pH, heat, and biotic stimuli, along with chlamydospore formation, centromeric and telomeric silencing, and protein localisation. The product localises to the actomyosin contractile ring, mitotic spindle midzone, cell division site, and extracellular vesicles. Phenotypic associations include increased acquired thermotolerance, premature cell cycle transitions, abnormal spore germination, increased sporulation, absent biofilm formation, and altered endocytosis and protein transport. Studies of related genes in other species link the family to virulence and stress responses.