RAS2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G23767 (RAS2) on chromosome 4 of Fusarium graminearum PH-1 encodes a small GTPase of the Ras-type family, possessing GTP, GDP, CTP and UTP binding activities, GTPase activity, G protein activity and protein serine/threonine kinase activator activity. The gene is associated with Ras protein signal transduction, positive regulation of the pheromone response MAPK cascade, regulation of conjugation with cellular fusion, conidia formation, spore germination, hyphal growth, cell polarization, regulation of cell shape, nitrate metabolism, and protein localization to the plasma membrane. Its product localizes to the plasma membrane, cytoplasm, nucleus, division septum, cell cortex of cell tips, Cdc42 GTPase complex, and mating projection actin fusion focus. Studies of related genes in other species link the family to reduced virulence.