IMP1 — Fusarium graminearum PH-1

Summary

FgIMP1 (FGRAMPH1_01G24061) on chromosome 4 of Fusarium graminearum PH-1 encodes an importin-alpha family protein with nuclear import signal receptor activity, NLS binding, identical protein binding, GTP binding, and protein membrane adaptor functions. The gene is associated with mitotic nuclear pore complex disassembly, regulation of mitotic nuclear envelope breakdown, and NLS-bearing substrate-nucleus import. It is linked to cell cycle progression, particularly G1/S and G2/M phase transitions, metaphase-anaphase transition, and cytokinesis. Associations extend to sexual reproduction, sporulation, vacuole inheritance, homotypic vacuole fusion, lipophagy, ribophagy, pexophagy, nucleophagy, mRNA processing, RNA splicing, and cell division. Phenotypic connections include altered nuclear import and export, chromosome segregation, mating type switching, endocytosis, peroxisomal distribution, hydrostatic pressure resistance, mutation frequency, chronological lifespan, and starvation resistance. The protein localizes to the nuclear periphery, nucleoplasm, nuclear membrane, nuclear envelope, lipid rafts, fungal-type vacuole membrane, and the NVJ.