ABC1 — Fusarium graminearum PH-1

Summary

FgABC1 (FGRAMPH1_01G24719) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with an atypical ADCK/ABC1 kinase domain, possessing kinase activity and ATP binding. The gene is associated with ubiquinone anabolism, phospholipid and lipid homeostasis, sterol anabolism, mitochondrial biogenesis, exocytosis, secretion, and vesicle transport. The product localizes to the mitochondrial inner membrane. Phenotypic associations include increased mitochondrial genome maintenance and mitophagy, increased vegetative growth and biofilm formation, decreased filamentous growth and sporulation efficiency, abnormal mitochondrial morphology and lipid particles, and altered cell cycle progression. Related genes in other species link this gene to respiratory chain function.