LAC1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G25365 (LAC1) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with cupredoxin domains. The enzyme exhibits ferroxidase and p-diphenol:oxygen oxidoreductase activities, binds copper, and is associated with redox activity. LAC1 is associated with lignin breakdown, reductive iron assimilation, cellular response to iron ion starvation, and sphingolipid anabolism. The protein localises to the extracellular high-affinity iron permease complex. Studies of related genes in other species connect the family to both reduced virulence and unaffected pathogenicity, though these associations are not established for LAC1 itself.