DO — Fusarium graminearum PH-1

Summary

FgDO (FGRAMPH1_01G26047) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with branched 1,3-beta-D-glucan synthase, callose synthase, and a-1,3-glucan synthase activities, belonging to the FKS1-like and Glyco_trans_48 domain families. This gene is associated with ascospore wall 1,3-beta-glucan anabolism, primary and secondary cell septum biogenesis, fungal-type cell wall polysaccharide biosynthesis, chitin anabolism, glycogen metabolism, mitotic division septum assembly, cell growth, and cell wall organization. The product localizes to the primary cell septum, spore wall, 1,3-beta-glucan synthase complex, cleavage furrow, growing cell tips, and the mitotic actomyosin contractile ring. Associations include decreased spore germination rate, abnormal shmoo formation, decreased adhesion, altered cell cycle progression, and reduced alkaline pH resistance. Studies of related genes in other species link the family to reduced virulence and fusarium head blight.