TAP42 — Fusarium graminearum PH-1

Summary

FgTAP42 (FGRAMPH1_01G26245) on chromosome 4 of Fusarium graminearum PH-1 encodes a TAP42/TAP46-like family protein that binds protein phosphatase 2A. The gene is associated with the regulation of TORC1 signaling, dephosphorylation, cell wall biogenesis, cell growth, and signal transduction, and its product localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations link FgTAP42 to increased virulence, altered cell cycle progression (including delayed progression, increased G1 phase, and altered S phase duration), abnormal chromosome segregation, decreased adhesion, and changes in resistance to alkaline pH, UV, and ionizing radiation. The gene is also associated with abnormal respiratory and fermentative metabolism, decreased necrotic cell death, and altered meiotic recombination. Studies of related genes in other species, such as yeast SIT4 and RAD53, place the TAP42 family within broader TOR signaling and cell cycle regulatory networks.