PTF1 — Fusarium graminearum PH-1

Summary

FgPTF1 (FGRAMPH1_01G26577) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a pyridoxal phosphate phosphatase-related domain and a haloacid dehalogenase (HAD)-like hydrolase/phosphatase fold, annotated with sorbitol-6-phosphatase, ribitol-5-phosphatase, and sn-glycerol 1-phosphatase activities, and magnesium binding. The gene is associated with chromatin organization and the DNA damage response, and its product localizes to the cytoplasm, cytosol, and nucleus. FgPTF1 is associated with abnormal plasma membrane, nuclear, endoplasmic reticulum, actin cytoskeleton, and mitochondrial morphology; increased cell death and apoptosis; decreased spore germination, mating efficiency, vegetative growth, nutrient uptake, vacuolar transport, endocytosis, telomere length, and resistance to alkaline pH, hydrostatic pressure, UV, cold, and enzymatic treatment; increased filamentous growth and cell size; and decreased rate of carbon source utilization and respiratory growth.