ASH2 — Fusarium graminearum PH-1

Summary

FgASH2 (FGRAMPH1_01G26783) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein containing a B30.2/SPRY domain and a ConA-like domain superfamily, and is annotated with transcription cis-regulatory region binding and zinc-binding molecular functions. The gene is associated with epigenetic regulation of gene expression, including chromatin-mediated maintenance of transcription, telomeric silencing, and regulation of secondary metabolism and mycotoxin anabolism. It is linked to hyphal growth, demethylation, and methylation processes, and localizes to the nucleus, chromatin, and telomeric regions. Phenotypic associations include abnormal cell cycle progression, increased aneuploidy and polyploidy, decreased colony size, altered budding patterns, reduced chitin deposition, and absent UV resistance. Related genes in other species connect it to reduced virulence.