LAC1 — Fusarium graminearum PH-1

Summary

FgLAC1 (FGRAMPH1_01G27129) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a Lag1/Lac1-like domain and TLC domain, localised to the endoplasmic reticulum membrane. The gene is associated with ceramide synthase activity, ceramide and sphingolipid biosynthesis, as well as hyphal growth and the meiotic cell cycle. It has also been connected to the FUM18, FUM17, and ALT7 proteins. Studies of related genes in other species link the LAC1 family to sphingosine N-acyltransferase activity and longevity-assurance functions, with sequence similarity to proteins from Verticillium dahliae and various Fusarium pathogens.