KIN1 — Fusarium graminearum PH-1

Summary

FgKIN1 (FGRAMPH1_01G27499) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a kinase-like domain and a KA1 domain, annotated with protein serine/threonine kinase activity and ATP binding. The gene is associated with multiple biological processes including mitotic cytokinesis site selection, positive regulation of cell cycle switching from mitotic to meiotic, negative regulation of cytoplasmic translation, regulation of invasive growth in response to glucose limitation, asexual reproduction, and fungal-type cell wall assembly. It is linked to phenotypes such as premature apoptosis, abnormal filamentous growth, absent hyperosmotic stress resistance, increased mating efficiency, and abnormal chitin deposition. Localization evidence connects the product to the cell cortex of growing and non-growing cell tips, the microtubule cytoskeleton, and the nucleotide-activated protein kinase complex. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.