ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (ABC2) on chromosome 4 of Fusarium graminearum PH-1 encodes an ABC transporter with domains characteristic of the ABC_transporter_C-like family, including ABC1 transmembrane and ATP-binding domains, and exhibits ATP hydrolase, haem-transporting ATPase, cadmium ion transmembrane transporter, and ABC-type phytochelatin/xenobiotic transporter activities. The gene is associated with heme export from vacuole to cytoplasm, cellular detoxification of cadmium ions, glutathione and PC2 import into vacuole, xenobiotic detoxification, response to metals and toxic substances, cichorine and sterol anabolism, homotypic vacuole fusion, filamentous growth in response to starvation or biotic stimulus, and secretion. The product localizes to the vacuolar membrane, fungal-type vacuole, Golgi complex, and plasmalemma. Phenotypic associations include altered vacuolar morphology and distribution, decreased endocytosis, abnormal cell cycle progression, increased entry into G0, and altered stress resistance.