ACL1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G30241 (symbol ACL1) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with citrate synthase and succinyl-CoA ligase domains, and is annotated with succinate-CoA ligase (GDP-forming and ADP-forming) and ATP citrate synthase activities. The gene is associated with the TCA cycle, citrate metabolism, succinyl-CoA metabolism, acetyl-CoA anabolism, and fatty acid anabolism. It is linked to mitochondrial and cytosolic localisation, as well as the large ribosomal subunit and translation. Studies of related genes in other species connect the ACL1 family to loss of pathogenicity and to fusarium head blight.