AMD1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G00297 (AMD1) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with an amidase domain and an AS superfamily domain, exhibiting urea carboxylase, allophanate hydrolase, fatty acid amide hydrolase, and general amidase activities, along with ATP and metal binding. This gene is associated with urea breakdown, demethylation, methylation, sexual reproduction, RNA breakdown, antibiotic anabolism, fatty acid breakdown, and hyphal growth. The product localizes to the cytoplasm, cytosol, nucleus, and extracellular space. Studies of related amidase family proteins in other fungi, including Verticillium dahliae and Fusarium oxysporum, link the family to amide hydrolysis, though these functions are not yet established for this specific gene.