ILV1 — Fusarium graminearum PH-1

Summary

FgILV1 (FGRAMPH1_01G00793) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with threonine deaminase, serine racemase, L-serine deaminase and D-serine ammonia-lyase activities, and binds pyridoxal phosphate, ATP and magnesium. It forms homodimers and localises to the cytoplasm and mitochondrial lumen. The gene is associated with L-isoleucine biosynthesis, L-serine catabolism, threonine breakdown and morphogenesis. Phenotypic associations include decreased filamentous and invasive growth, reduced sporulation, impaired carbon-source utilisation, increased cold sensitivity, altered cell-cycle progression in G1 phase, abnormal mitochondrial morphology and genome maintenance, and decreased fermentative and respiratory growth. Related genes in other species link the family to threonine deaminase activity and nitrogen-source utilisation.