ACS1 — Fusarium graminearum PH-1

Summary

FgACS1 (FGRAMPH1_01G00867) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with amide synthase and acetate-CoA ligase activities, containing AMP-binding and acetyl-CoA ligase domains. The gene is associated with perithecium development, acetoin and acetate breakdown, acetyl-CoA biosynthesis, penicillin biosynthesis, lipogenesis, ethanol fermentation, and heterotrophy. It has been linked to abnormal carbon source utilization, decreased fermentative metabolism and growth, decreased ribophagy, abnormal vacuolar and Golgi morphology, absent adhesion, absent pheromone sensitivity and production, sterility, absent nutrient uptake, increased X-ray resistance, delayed cell cycle progression, and increased critical cell size at the G1 checkpoint. The product localizes to the nucleolus, cytosol, and extracellular space. Studies of related genes in other species link the family to protein content.