ATG11 — Fusarium graminearum PH-1

Summary

FgATG11 (FGRAMPH1_01G01003) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing Atg11_C and ATG17-like domains, with protein serine/threonine kinase activator activity, protein kinase binding, and bridging functions. The gene is associated with autophagy, including macroautophagy, mitophagy, ribophagy, ER-phagy, pexophagy, and piecemeal microautophagy of the nucleus (PMN), as well as cellular response to nitrogen starvation, response to starvation, vacuolar transport, protein transport, proteolysis, and morphogenesis. Its product localizes to the ULK complex, phagophore assembly site (PAS) and its membrane, vacuolar membrane, cytoplasm, and nucleus. Studies of related genes in other species link the family to altered virulence, including hypervirulence and reduced virulence.