PMR1 — Fusarium graminearum PH-1

Summary

FgPMR1 (FGRAMPH1_01G01297) on chromosome 1 of Fusarium graminearum PH-1 encodes a P-type ATPase with cation-transporter domains, annotated with potassium:proton, sodium, manganese and calcium transporter activities as well as ATP hydrolase activity. The gene is associated with ion export processes including potassium, sodium, calcium and manganese transport, cellular pH reduction, calcium ion release from the Golgi, and responses to unfolded proteins. It localises to the plasma membrane, cell tip, Golgi, ER, vacuolar membrane and nuclear envelope. Phenotypic associations include decreased spore germination, abnormal flocculation, altered cell cycle progression, increased necrotic cell death, and absent meiotic recombination. Studies of related genes in other species link the family to manganese sensitivity and loss of pathogenicity.