ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (ABC2) on chromosome 1 of Fusarium graminearum PH-1 encodes an ABC transporter with haem-transporting ATPase activity, ABC-type phytochelatin and xenobiotic transporter activities, heme binding, ATP hydrolase activity, ATP binding, and metal binding. It is associated with haem export from vacuole to cytoplasm, glutathione transport into vacuole, PC2 import into vacuole, cellular detoxification of cadmium ion, response to toxic substances, cichorine and sterol anabolism, xenobiotic detoxification by transmembrane export across the plasma membrane, interaction with host, secretion, membrane transport, and homeostasis. The gene is linked to extracellular vesicles, vacuolar membrane, fungal-type vacuole, Golgi complex, plasmalemma, and cytoplasm. Phenotypic associations include altered oxidative and osmotic stress resistance, abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, abnormal cell cycle progression, and changes in colony color, protein accumulation, and fermentative metabolism.