CMK2 — Fusarium graminearum PH-1

Summary

FgCMK2 (CMK2) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with serine/threonine kinase activity, including calcium/calmodulin-dependent kinase activity, protein kinase A activity, and histone H3S10 kinase activity, and binds calmodulin and ATP. The gene is associated with the regulation of mitotic and meiotic processes, including spindle assembly checkpoints, chromosome segregation, and reciprocal meiotic recombination. It is linked to the positive regulation of spore germination and the negative regulation of calcineurin-mediated signaling. FgCMK2 is associated with abnormal cell cycle progression, increased polyploidy, and absent resistance to osmotic stress, UV, and desiccation, as well as increased freeze-thaw resistance. The encoded protein localizes to the kinetochore microtubule, spindle midzone, and CPC complex.