GUA1 — Fusarium graminearum PH-1

Summary

FgGUA1 (FGRAMPH1_01G02161) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with IMP dehydrogenase activity, nucleotide binding and metal binding, and contains IMP dehydrogenase, CBS and aldolase-type TIM barrel domains. The gene is associated with GMP and GTP anabolism, XMP salvage, AMP breakdown, prevention of self-toxicity, terpenoid anabolism, and perturbation of host immune response. It is linked to both asexual and sexual reproduction, filamentous growth, cellular responses to starvation and xenobiotic stimuli, and cytoplasmic and cytosolic localisation. Phenotypic associations include absent filamentous growth, abnormal cell cycle progression, and defects in cell fusion, budding, mating projection morphology, autophagy, pexophagy, cytokinesis, and nutrient utilisation. Related genes in other species link the family to similar nucleotide metabolism and growth processes.