GCV1 — Fusarium graminearum PH-1

Summary

FgGCV1 (FGRAMPH1_01G02859) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with aminomethyltransferase and transaminase activity, a component of the glycine cleavage system. The protein localises to the mitochondrial lumen and is associated with glycine and threonine metabolism, glycine decarboxylation, and sexual reproduction. The gene has been linked to numerous phenotypes, including decreased vegetative growth, competitive fitness, hyperosmotic stress resistance, desiccation resistance, and chronological lifespan, as well as increased innate thermotolerance and metal resistance. Associations also include abnormal chromosome maintenance, vacuolar morphology, and altered chemical compound accumulation. Related genes in other species link the family to nitrogen source utilisation and killer toxin resistance, though these associations are not established for FgGCV1 itself.