CHS3 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G03149, designated CHS3 (also known as CHS4, FgCHSF, FgCHS3, FgCHS4, FgCHS-4) on chromosome 1 of Fusarium graminearum PH-1, encodes a chitin synthase with a CHS4-like domain and nucleotide-diphosphosugar transferase domain, conferring chitin synthase activity. This gene is associated with cell wall biogenesis, chitin anabolism, hyphal growth, asexual sporulation (conidia formation), ascospore wall assembly, homologous recombination, and response to mechanical stimulus. The encoded protein localizes to the chitosome, plasma membrane, cross wall, bud neck, and extracellular vesicles. Phenotypic associations include abnormal septum formation, chitin deposition, spore wall formation, bud neck morphology, and cell cycle progression, as well as decreased adhesion, cell fusion, and pheromone production, with increased alkaline pH resistance. Related genes in other species link the family to chitin synthase function and EC 2.4.1.16, while sequence similarity connections extend to polysaccharide content and salt tolerance traits.