TEX1 — Fusarium graminearum PH-1

Summary

FgTEX1 (FGRAMPH1_01G03199) on chromosome 1 of Fusarium graminearum PH-1 encodes a Tex1/THOC3 family protein containing WD40 repeats, with annotated DNA-binding transcription repressor activity, transcription corepressor activity, and binding capacities for mediator complex, histone deacetylase, dynein complex, microtubule plus-ends, GTP, and ubiquitin ligase substrate adaptor function. The gene is associated with the THO/TREX complex, transcription repressor complex, SCF complex, microtubule-associated complex, spindle pole, kinetochore, and histone methyltransferase complex. Biologically, it is linked to negative regulation of isoprenoid metabolism, mitigation of host defenses, regulation of fatty acid anabolism, HOG response, quorum sensing, mRNA-nucleus export, development of symbiont in host, and negative regulation of filamentous growth. Phenotypic associations include abnormal meiosis, cell cycle arrest, decreased spore germination, absent vegetative growth, abnormal sporulation, increased telomere length, and altered colony appearance. Studies of related genes in other species link the family to reduced virulence.