PRS — Fusarium graminearum PH-1

Summary

FgPRS (FGRAMPH1_01G03291) on chromosome 1 of Fusarium graminearum PH-1 encodes a proline-tRNA ligase, a member of the prolyl-tRNA synthetase family, with proline-tRNA ligase activity and ATP binding. The gene is associated with phytoalexin biosynthesis, the MAPK cascade, and mitochondrial translation, and its product localizes to the mitochondrial lumen and mitochondria. Phenotypic associations include abnormal RNA localization and nucleolar morphology, increased nucleolar size, increased filamentous growth, inviability, increased heat sensitivity, haploinsufficiency, decreased vegetative growth and competitive fitness, and decreased chemical resistance. Studies of related genes in other species link the family to abnormal mitochondrial genome maintenance, increased mutation frequency, and decreased respiratory growth and chronological lifespan.