CSN12 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G03715 (CSN12) in Fusarium graminearum PH-1 encodes a Csn12-like protein containing a PCI domain and a WH-like DNA-binding superfamily domain, with annotated dsDNA and RNA binding activities. The gene is associated with the TREX-2 complex, the COP9 signalosome (CSN), the nuclear envelope, cytoplasm, cytosol, and nucleus. It is linked to sexual reproduction, posttranscriptional tethering of RNA polymerase II gene DNA at the nuclear periphery, poly(A)+ mRNA nuclear export, and RNA elongation from the Pol II promoter. Phenotypic associations include altered shmoo formation, mating efficiency, meiosis, pheromone sensitivity, spore germination, vegetative growth, sporulation, autophagy, mitochondrial genome maintenance, mutation frequency, telomere length, and resistance to enzymatic treatment. Studies of related genes in other species link the family to the COP9 signalosome and proteasome regulatory subunit RPN5.