ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G04099) on chromosome 1 of Fusarium graminearum PH-1 encodes an ABC-type oligopeptide transporter with ATP hydrolase activity and ATP-coupled transmembrane transporter activity. The protein belongs to the type 1 exporter family and is localized to the mitochondrial inner membrane, plasma membrane, and general membrane. It is associated with oligopeptide export from mitochondria, sterol anabolism, secretion, membrane transport, and homeostasis. Phenotypic associations link the gene to altered cell cycle progression, including increased G2/M phase transition and entry into G0, decreased endocytosis and hyperosmotic stress resistance, abnormal vacuolar morphology and peroxisomal distribution, increased pexophagy, and abnormal colony color. The gene is also associated with oxidative stress resistance, protein/peptide accumulation, and nuclear export. Studies of related genes in other species link the family to additional processes including leaf morphology.