CAT2 — Fusarium graminearum PH-1

Summary

FgCAT2 (FGRAMPH1_01G04645) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with carnitine O-acetyltransferase activity and fatty acid synthase activity, containing a CAT-like domain superfamily. The gene is associated with coenzyme A and acetyl-CoA transport, carnitine metabolism, fatty acid metabolism and biosynthesis, secondary metabolite biosynthesis, antibiotic anabolism, and methylation. The product localises to the peroxisome and mitochondrial inner membrane. FgCAT2 has been linked to numerous phenotypes including increased vegetative and pseudohyphal growth, increased anaerobic growth and freeze-thaw resistance, decreased mating response and invasive growth, abnormal cell wall morphology, and increased lifespan and starvation resistance. Related genes in other species connect it to oxidative stress response.