ARB1 — Fusarium graminearum PH-1

Summary

FgARB1 (FGRAMPH1_01G04891) on chromosome 1 of Fusarium graminearum PH-1 encodes a member of the ABCF subfamily of ATP-binding cassette proteins, possessing translation elongation factor activity, ribosome and RNA binding, and ATP hydrolase activity. The gene is associated with cytoplasmic translational initiation, elongation, and termination, as well as protein localization to the plasma membrane, nuclear export, ribosome biogenesis, and regulation of translation. The product localizes to the cytosolic ribosome, cytoplasm, nucleus, stress granules, and the fungal biofilm matrix. Phenotypic associations include increased lifespan, increased vegetative growth rate, increased starvation resistance, increased desiccation and acid pH resistance, decreased cold sensitivity, decreased cell death, abnormal colony shape, decreased chromosome segregation, and delayed cell cycle progression in S phase. Related genes in other species link the family to ribosome biogenesis and translation.