IRC5 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G04893 (IRC5, also known as INO80) encodes an ATP-dependent chromatin remodeler with DNA helicase activity, histone binding, and ATP hydrolase activity, belonging to the INO80/SWR1 helicase family. In Fusarium graminearum PH-1, this gene is associated with regulation of TOR signaling, CENP-A containing chromatin assembly, telomere maintenance via recombination, deubiquitination, transcription by RNA polymerase II, telomeric silencing, chromatin modeling, DNA repair, and positive regulation of transcription. It localizes to the Ino80 complex, centromere complex, and telomeric regions. Phenotypic associations include normal cell cycle progression, increased G1/S phase transition duration, absent mutation frequency, abnormal transposable element transposition, decreased cell death rate, and abnormal replicative lifespan. Studies of related genes in other species link the family to loss of pathogenicity and fusarium head blight.