GRX1 — Fusarium graminearum PH-1

Summary

FgGRX1 (GRX1) on chromosome 1 of Fusarium graminearum PH-1 encodes a glutaredoxin with glutathione disulfide oxidoreductase and glutathione peroxidase activities. The protein localises to the cytoplasm, cytosol, nucleus and mitochondria. It is associated with cellular responses to oxidative stress and the removal of superoxide radicals. The gene has been linked to numerous phenotypes, including normal filamentous growth, abnormal shmoo formation, increased pheromone sensitivity, decreased chitin deposition, abnormal cell wall morphology, decreased spore germination, decreased osmotic and ionic stress resistance, decreased acquired thermotolerance, decreased exponential-phase growth, increased lifespan, decreased apoptosis, abnormal cell cycle progression in G1 phase, increased mitotic recombination, and altered pseudohyphal growth. It is also connected to decreased fermentative metabolism and growth, abnormal autophagy, absent pexophagy, and petite-negative status. Related genes in other species link the glutaredoxin family to oxidative stress response.