CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G05103) on chromosome 1 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with oxidoreductase activity, heme and iron binding, and is associated with the endoplasmic reticulum and membrane. The gene is associated with ergosterol, mycotoxin, fumonisin, antibiotic, and small molecule biosynthesis. Associations with numerous phenotypes include decreased colony size, vegetative growth arrest, increased cell death, abnormal cytoskeleton and plasma membrane morphology, decreased meiosis and mating response, absent micronucleophagy and protein secretion, and altered cell cycle progression, budding, endocytosis, and vacuolar transport. Studies of related genes in other species connect the family to potassium concentration and acid sensitivity.