ILV3 — Fusarium graminearum PH-1

Summary

FgILV3 (FGRAMPH1_01G04959) on chromosome 1 of Fusarium graminearum PH-1 encodes a dihydroxy-acid dehydratase, an enzyme with dihydroxy-acid dehydratase activity that binds a 2Fe-2S cluster and metal ions. This gene is associated with branched-chain amino acid biosynthesis, including valine, isoleucine, and leucine anabolism, as well as hyphal growth. The product localises to mitochondria and the mitochondrial lumen. FgILV3 is associated with numerous phenotypes, including altered vegetative growth, increased osmotic stress resistance, abnormal cell cycle progression, absent autophagy, decreased fermentative metabolism, abnormal meiosis, increased viability, and increased respiratory growth. It is also linked to abnormal mitochondrial genome maintenance, increased apoptosis, and altered nutrient utilisation. Related genes in other species are linked to reduced virulence and invasive pulmonary aspergillosis.