VPS52 — Fusarium graminearum PH-1

Summary

FgVPS52 (FGRAMPH1_01G04717) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing Vps52_CC and Vps52_C domains and is associated with syntaxin binding. The gene product is a component of the GARP complex and localizes to the Golgi complex and cytosol. It is linked to endocytic recycling, retrograde transport from endosome to Golgi, Golgi-to-vacuole transport, and intracellular protein transport. FgVPS52 has been connected to numerous phenotypes including absent sporulation efficiency, abnormal septum formation, decreased invasive growth, arrested vegetative growth, increased cell death, abnormal cell wall morphology, absent endocytosis and autophagy, decreased meiosis, and abnormal prion inheritance. It is also associated with absent innate thermotolerance, decreased utilization of iron sources, and abnormal plasma membrane morphology and mitochondrial distribution.