HSC82 — Fusarium graminearum PH-1

Summary

FgHSC82 (FGRAMPH1_01G04861) on chromosome 1 of Fusarium graminearum PH-1 encodes an ATP-dependent protein folding chaperone belonging to the Hsp90 family, with ATP hydrolase activity and ATP binding. This gene is associated with protein folding, stabilization, and the assembly of multidomain proteins, proteasomes, and Box C/D snoRNPs. It is linked to responses to heat and xenobiotic stimuli, regulation of apoptotic processes, and filamentous growth. Localization evidence connects the product to the hyphal cell wall, cross wall, extracellular vesicles, mitochondria, and the perinuclear cytoplasm. Phenotypic associations include increased thermotolerance, premature apoptosis, abnormal spore germination, decreased hypoosmotic stress resistance, altered cell cycle progression, and absent biofilm formation and flocculation. Studies of related genes in other species link the family to reduced virulence.