VPS5 — Fusarium graminearum PH-1

Summary

FgVPS5 (FGRAMPH1_01G04855) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing BAR_Vps5, PX_Vps5, and Vps5_C domains. The product binds phosphatidylinositol-3-phosphate and other phosphoinositides. FgVPS5 is associated with retromer complex and SNX-BAR dimer localisation, and is linked to endosome and mitochondrial membranes. The gene has been connected to multiple vesicle-mediated processes including retrograde transport from endosome to Golgi, endocytic recycling, vacuolar protein sorting, and protein transport. It is also associated with autophagy-related pathways such as mitophagy, ER-phagy, and piecemeal microautophagy of the nucleus (PMN), as well as ascospore formation. Studies of related genes in other species link the family to reduced virulence and associations with diseases including fusarium head blight and rice blast.