CI-1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G04729 (CI-1, also known as ERG5A) on chromosome 1 of Fusarium graminearum PH-1 encodes a cytochrome P450 family protein with C-22 sterol desaturase (NADPH) activity, aflatoxin B synthase activity, and monooxygenase activity, and it binds iron and heme. The gene is associated with ergosterol and terpenoid biosynthesis, sterol metabolism, and small molecule biosynthesis. It is linked to filamentous growth, including responses to starvation and biotic stimuli, and localizes to the endoplasmic reticulum membrane and plasma membrane. Associations with numerous phenotypes have been observed, including decreased colony size, increased cell death, abnormal plasma membrane morphology, decreased mating response, and arrested vegetative growth. Studies of related genes in other species link the family to reduced virulence and fusarium head blight.