ACS1 — Fusarium graminearum PH-1

Summary

FgACS1 (FGRAMPH1_01G04241) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with amide synthase and acetate-CoA ligase activities, containing AMP-binding and acetyl-CoA ligase domains. The gene is associated with perithecium development, acetoin and acetate breakdown, acetyl-CoA biosynthesis, penicillin biosynthesis, lipogenesis, ethanol fermentation, and coenzyme A/acetyl-CoA transport. It localises to the nucleolus, cytosol, and extracellular space. Phenotypic associations include abnormal carbon source utilisation, decreased pheromone production, absent pheromone sensitivity, decreased fermentative growth and metabolism, increased X-ray resistance, sterility, abnormal spore wall formation, and increased critical cell size at the G1 checkpoint. Related genes in other species link the family to protein content traits.